Avoiding Interferences in Advance: Cyclodextrin Polymers to Enhance Selectivity in Extraction of Organic Micropollutants for Carbon Isotope Analysis

today’s cyclodextrin:
CDs in carbon isotope analysis
Compound-specific isotope analysis (CSIA) of organic water contaminants can provide important information about their sources and fate in the environment. Analyte enrichment from water remains nonetheless a critical yet inevitable step before measurement. Commercially available solid-phase extraction (SPE) sorbents are inherently nonselective leading to co-extraction of concurrent dissolved organic matter and in turn to analytical interferences, especially for low-occurring contaminants. Using cyclodextrin polymers (α-, β-, γ-CDP) as SPE sorbents (i) extraction selectivity was increased, (ii) their applicability to carbon isotope analysis for a selection of pesticides was assessed, and (iii) they were compared with commonly used commercial sorbents. Extraction with β-CDP significantly reduced backgrounds in gas chromatography-isotope ratio mass spectrometry (GC-IRMS) and enhanced sensitivity by a factor of 7.5, which was further confirmed by lower carbon-normalized CDOM/Canalyte ratios in corresponding extracts as derived from dissolved organic carbon (DOC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The present study highlights the benefit of selecting innovative extraction sorbents to avoid interferences in advance. This strategy in combination with existing cleanup approaches offers new prospects for CSIA at field concentrations of tens to hundreds of nanograms per liter.

Martin Elsner and Rani Bakkour et al

See the full article here

Othon Moultos has been awarded an NWO OTP grant of 1 million euros for water treatment research

today’s cyclodextrin:
using CDs in wastewater treatment has been around for decades. Nowadays, this application is industrially pioneered by Cyclopure. This research field may experience a new booster, as Othonas Moultos of the Delft University of Technology received a 1M Euro award for his project “SYROP – Intelligent design of sustainable Sugar(cYclodextrin)-based adsorbents for the Removal of Organic microPollutants and PFAS from water’’ from NWO (Dutch Research Council).
The SYROP team also includes top researchers from the industry: Yuhan Ling, and Gokhan Barin from Cyclopure Dr. van der Hoeke from Waternet (the water utility of Amsterdam and surroundings), and de Jong and Dr. Nieuwenhuijzen from Wittenveen+Bos (a company with 4000+ projects experience in environmental engineering). SYROP will combine for the first time advanced molecular modeling, machine learning, and experimentation to design and develop a new generation of sustainable and efficient sugar-based adsorbents that can selectively remove high-priority harmful components during water treatment.

See the press release here

Othon Moultos