Using CDs to stabilize drugs chemically is rather frequently used. But did you know that they can also be used to stabilize radiopharmaceuticals? According to the patent of GE HealthCare (Kristine Opsvik Wikene; Kahn Imtiaz Ahmed; Graeme McRobbie) combined with a radiostabilizer (like ascorbic acid), a cyclodextrin as co-stabilizer improves the stability of radiopharmaceuticals compared to using a conventional stabilizer.
In vivo assessment of tumor targeting potential of 68Ga-labelled randomly methylated beta-cyclodextrin (RAMEB) and 2-hydroxypropyl-β-cyclodextrin (HPβCD) using positron emission tomography
This novel application is a fascinating combination of tumor targeting and diagnosis using of 68Ga-labelled cyclodextrin for positron emission tomography of PGE2-positive tumors.
University of Debrecen – Gabor Opposits, István Jószai, Istvan Kertesz, Zita Képes, Méhes Gábor, Ferenc Fenyvesi István Hajdu, György Trencsenyi