Evaluation of polyanionic cyclodextrins as high affinity binding scaffolds for fentanyl

Fascinating application shared by Lawrence Livermore National Laboratory – Edmond Lau et al. on the synthesis of new CDs possessing extended thioalkylcarboxyl or thioalkylhydroxyl moieties and assess their binding affinity towards fentanyl hydrochloride. The performance of these host molecules portends their utility as platforms for medical countermeasures for opioid exposure, as biosensors, and in other forensic science applications.

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