Egyéb kategória - CarboHyde

Impacts of β-cyclodextrin bead polymer (BBP) treatment on the quality of red and white wines: Color, polyphenol content, and electronic tongue analysis

Feb 15, 2023adminEgyéb kategória

This is a really creative study presented by the University of Pécs – John-Lewis Zinia Zaukuu, PhD, Lajos Szente,, Miklós Poór, et al., who examined the effects of insoluble β-CD bead polymer (BBP) on the quality of red and white wines – evaluated the BBP-induced changes in the color, the total polyphenol content as well as in the trans-resveratrol and quercetin concentrations of wine samples. Furthermore, e-tongue analyses were also performed as a highly sensitive tool to examine the influence of BBP on the taste of wines.

See the full article here

Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five

Dec 21, 2022adminEgyéb kategória

In this creative paper Sven Stegemann, Amrit Paudel (Technische Universität Graz), Chris Moreton (FinnBrit Consulting), Sami Svanbäck (The Solubility Company), Karl Box (Pion Inc.), and Genevieve Motte (JEN Pharma Consulting) analyze trends in oral drug product development.

See the full article here or read the pdf below

Trends-in-oral-small-molecule-drug-discovery-and-product-development-based-on-product-launches-before-and-after-the-Rule-of-Five Download

Procedure of predicting type 2 diabetes development through analysis of n-glycans attached to the plasma proteins of a healthy person

Oct 25, 2022Tamas SohajdaEgyéb kategória

It’s worth celebrating this discovery by Genos Ltd – Gordan Lauc, Olga Gornik, Frano Vučković, Ivan Gornik on using predicting type 2 diabetes via N-glycan patterns of plasma proteins. Which inventions make glycochemistry shine and show its importance!

Read the full patent on espacenet

What is the story of a pharma startupper?

Oct 10, 2022Tamas SohajdaEgyéb kategóriacarbohyde, józsef Tóth

To better understand the place and the goals of CarboHyde, a private preclinical pharma startup from the EU, a short interview was performed with József Tóth Ph.D., Founder, and CEO of CarboHyde.

Read the full interview below in pdf form

Interview-Jozsef_Toth Download

Identification of a βCD-Based Hyper-Branched Negatively Charged Polymer as HSV-2 and RSV Inhibitor

Sep 21, 2022Tamas SohajdaEgyéb kategóriaantiviral, covid19, HIV, influenza

Cyclodextrin derivatives were demonstrated to be endowed with intrinsic antiviral action against several viruses (herpes, HIV, RSV, influenza, covid19, etc.). In this great work from Rachele Francese, Francesco Trotta, Claudio Cecone, Matteo Constantino, Gjylije Hoti, Pierangiola Bracco, and David Lembo from the University of Turin, four water-soluble hyper-branched beta cyclodextrin anionic polymer were screened against herpes simplex virus (HSV-2), respiratory syncytial virus (RSV), rotavirus (HRoV), and influenza virus (FluVA). The results suggest that the polymer virucidal activity against RSV can be exploited to produce new antiviral materials to counteract the virus dissemination through the air or direct contact.

The effect of alpha-cyclodextrin on post-prandial glucose excursions, a systematic meta-analysis

Sep 16, 2022Tamas SohajdaEgyéb kategóriablood glucose, diabetes, dietary supplement

An interesting idea proposed by Knut M. Wittkowski for the novel use of alpha-#cyclodextrin:
The effect of alpha-cyclodextrin on post-prandial glucose excursions, a systematic meta-analysis
For more details, click here

Methods for treatment of familiar heterozygous and homozygous hypercholesterolemia with cyclodextrins

Sep 16, 2022Tamas SohajdaEgyéb kategóriaatheroclerosis

Using cyclodextrins, especially 2-hydroxypropyl-beta-CD for the treatment of atherosclerosis has a hype, there are several companies and research groups chasing this holy grail. Fresh from the oven is the patent application from Beren Therapeutics explaining methods of treating familial hypercholesterolemia via different mechanisms of action.