Polarizer and image display device

Today's cyclodextrin

today’s cyclodextrin:
Conventional LCDs have a drawback of sensitivity to high temperatures. However, mobile phones and in-vehicle applications (such as car navigation systems) and various touch panel instruments with such display(s) are often exposed to harsh conditions. Sumitomo Electric’s polarizing plate has a polarizing element in which a dichroic dye is adsorbed and oriented on a polyvinyl alcohol-based resin layer and a transparent protective film containing a compound having nitroxy radical/ group and cyclodextrin. The model LCD panel well tolerated as high temperatures as 105 Celsius for an extended period of time (240 hours).

See the original patent on Espacenet

University of Sydney and CarboHyde join forces in groundbreaking collaboration to combat natural toxins

news

University of Sydney, a leading innovator in researching natural toxins and poisons, and CarboHyde, a renowned expert in developing therapeutic carbohydrates are proud to announce their strategic partnership in the fight against natural toxins. This groundbreaking collaboration aims to advance research, develop effective solutions, and raise awareness about the detrimental impact of natural toxins on human health.

The world faces a growing threat from natural toxins, which can be found in various forms, including harmful algal blooms, venomous organisms, and poisonous plants. These toxins pose significant challenges to public health, wildlife, and ecosystems, demanding immediate attention and collaborative efforts to mitigate their harmful effects.

By combining their unique expertise, University of Sydney, led by Greg Neely and CarboHyde will work hand in hand to develop innovative technologies and approaches for neutralizing natural toxins and developing antidotes against poisoning or for prevention. “Our joint efforts will not only enhance the scientific understanding of these toxins but also pave the way for effective preventive measures and responsive strategies” – said Joseph Toth, CEO of CarboHyde. “Natural toxins present a complex and multifaceted challenge, requiring interdisciplinary solutions. This collaboration allows us to leverage our respective strengths and resources to address this pressing issue collaboratively. Together, we aim to develop comprehensive strategies that safeguard public health.” he added. 

The partnership between the University of Sydney and CarboHyde signifies a milestone in the fight against natural toxins. By combining their research capabilities, technical expertise, and industry knowledge, these two partners are committed to making significant contributions to toxin detection, risk assessment, and effective mitigation strategies.

Reduction of thyroid radioactive iodine exposure by oral administration of cyclic oligosaccharides

drug development, ,

Radioactive iodine may cause thyroid cancer and hypofunction and accordingly must be properly managed. If the absorption of radioactive iodine is suppressed, it can be expected to lead to a reduction in thyroid exposure. This study the inhibition of radioactive iodine absorption by the oral administration of α-cyclodextrin is shown in a murine model. The uptake of radioactive iodine into the thyroid gland in mice administered with radioactive iodine and an α-cyclodextrin solution was approximately 40% lower after 24 h. The finding that oral uptake of α-cyclodextrin has an inhibitory effect on the transfer of radioactive iodine to the thyroid gland has potential for application in many fields such as food, pharmaceuticals, nuclear emergency preparedness, and medicine.
Kumamoto University, JAPAN

See the full article on nature.com

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

drug delivery, Today's cyclodextrin,

today’s cyclodextrin:
Drug complexes: Perspective from Academic Research and Pharmaceutical Market
Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed.
Siva Ram Munnangi, Ahmed Youssef, Nagarjuna Narala, Preethi Lakkala, Sagar Narala, Sateesh Kumar Vemula, Ph.D. & Michael Repka  

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ɑ-cyclodextrin (A), β-cyclodextrin (B), γ-cyclodextrin (C), Hydroxypropyl-β-cyclodextrin (D), Cucurbit(7)uril (E), Cucurbit(8)uril (F), sulfonatocalix(4)arene (G) & sulfonatocalix(8)arene (H).

Encapsulation of Fragrances in Micro- and Nanocapsules, Polymeric Micelles and Polymersomes

Today's cyclodextrin

today’s cyclodextrin:
Fragrances are ubiquitously and extensively used in everyday life and several industrial applications, including perfumes, textiles, laundry formulations, hygiene household products, and food products. However, the intrinsic volatility of these small molecules leaves them particularly susceptible to fast depletion from a product or from the surface they have been applied to. Encapsulation is a very effective method to limit the loss of fragrance during their use and to sustain their release, as summarized by Sam Russell and Nico Bruns.
This review gives an overview of the different materials and techniques used for the encapsulation of fragrances, scents, and aromas, as well as the methods used to characterize the resulting encapsulation systems, with a particular focus on cyclodextrins, polymer microcapsules, inorganic microcapsules, block copolymer micelles, and polymersomes for fragrance encapsulation, sustained release, and controlled release.

See the article here: Encapsulation of Fragrances in Micro- and Nanocapsules, Polymeric Micelles and Polymersomes

A molecular information ratchet using a cone-shaped macrocycle

carbohydrates

Cyclodextrin-based molecular information ratchet on the cover of Chem. This novel type of ratchet, an autonomous, chemically fueled small-molecule motor is sensitive to two types of information: the position and the orientation of a moving macrocycle on an axle.
enxu LIU, Sawsen Cherraben, Laora Boulo, Claire Troufflard, Bernold Hasenknopf, Guillaume Vives, Matthieu Sollogoub 

See the article here

Absorbent article with odor control composition

Today's cyclodextrin

today’s cyclodextrin:
is Procter & Gamble‘s invention: a disposable absorbent article having a top sheet, a back sheet, and an absorbent core disposed in between. The disposable absorbent article includes an odor control composition having a preservative, a surfactant, methylated beta-cyclodextrin, and perfume. The intentions primary use is proposed in feminine hygiene pads.
Chad Weldishofer

See the full patent here

Can ChatGPT pass Glycobiology?

carbohydrates,

Can ChatGPT pass Glycobiology?
Devin Ormsby Williams and Elisa Fadda we were interested in testing the boundaries of the LLM ChatGPT (www.openai.com) in areas of complex scientific writing tasks and exam-type questions in Carbohydrate Chemistry and Glycobiology. The results of this project allowed to gain insight on,
1) the strengths and limitations of the ChatGPT model to provide relevant and (most importantly) correct scientific information, and
2) the format(s) and complexity of the query required to obtain the desired output.
Ultimately, with the support of practical examples the aim is to inspire educators on how to successfully integrate ChatGPT in teaching, learning and assessment in higher education.

See the article here

The electrochemical quantitation method for sugammadex via a molecularly imprinted polymer-based sensor

carbohydrates,

Sugammadex (SUG) is a synthetically modified γ-cyclodextrin derivative used in hospitals after surgeries to reverse the neuromuscular blockade induced by rocuronium or vecuronium. Who has experience in the field knows that analysis (in particular those human samples) of carbohydrates and cyclodextrin are very challenging.
In this study, Ankara University and DEVA Holding A.Ş. present the first electroanalytical quantification method for sugammadex by using molecular imprinting (MIP) via the electropolymerization (EP) technique. An EP-MIP film was formed by EP on a screen-printed gold electrode (SPAuE) and a new electrochemical sensor, EP-MIP(SUG)/SPAuE, was fabricated using the 4-aminophenol monomer with copper ions to enhance the MIP-binding site. Surface and electrochemical characterization of the EP-MIP(SUG)/SPAuE sensor have been done via scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The specificity/selectivity of the developed sensor has been shown by using common interferents found in the biological fluids and also molecules having similar structures, such as α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin. As a result, a quantitative analysis method has been developed and validated by using the EP-MIP(SUG)/SPAuE sensor in the concentration range of 0.1–1.0 pM with very high sensitivity (limit of detection: 27.3 fM). The applicability of the method has been shown for bulk drug substances, pharmaceutical dosage forms, and commercial serum samples.
Göksu Özçelikay, AHMET CETINKAYA, Esen BELLUR ATİCİ, Sibel A. OZKAN 

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