The first secondment at Bicyclos has been completed

Kristóf Felegyi just completed CarboHyde’s very first secondment under the scope of the Bicyclos HEurope project under the strong support of Csenge Anna Felegyi-Tóth.

Kristof worked for 5 months in the lab of Jose Manuel Garcia Fernandez under the supervision of Juanma Benito and created various cyclodextrin polymers that we will evaluate for gene and small molecule delivery.
😎
We appreciate the strong support and hospitality of CSIC and look forward to further collaborations.

As Kristof did not take a single photo in the lab, we can only trust he did not only do sightseeing in the wonderful city

Kristof Felegyi, Bicyclos, CarboHyde, Seville

CarboHyde CEO Tamas Sohajda Presents at CPHI NA on Novel Uses of Cyclodextrins in the Pharmaceutical Industry

CarboHyde CEO Tamas Sohajda recently delivered a compelling presentation at the CPHI North America conference, focusing on innovative applications of cyclodextrins in the pharmaceutical industry. His talk highlighted how these unique cyclic oligosaccharides can enhance drug delivery, improve solubility, and stabilize formulations, offering significant benefits to pharmaceutical development.

Cyclodextrins, known for their ability to form inclusion complexes with various molecules, have been extensively studied for their potential to revolutionize drug formulations. Sohajda’s presentation delved into recent advancements and case studies demonstrating the successful integration of cyclodextrins in new drug delivery systems. These developments promise to improve the efficacy and safety of numerous medications, addressing longstanding challenges in drug formulation and bioavailability.

The talk received considerable attention from industry professionals, underscoring CarboHyde’s leading role in pioneering the use of cyclodextrins for pharmaceutical innovation. Attendees had the opportunity to engage with Sohajda, discussing cyclodextrin research’s practical applications and future directions.

A video of the event is available on CPHI website – after a registration – for those who missed the presentation or wish to revisit the insights shared.

CPHI: Lightning Round: Excipients 4.0 – Cyclodextrins (CDs) (video) (cphi-online.com)

On Vimeo:

Dr Tamas Sohajda Lightning Round Excipients 4.0 – Cyclodextrins CDs on Vimeo

Stay tuned for more updates from CarboHyde as they continue to push the boundaries of pharmaceutical technology.

GENEGUT meeting in Porto

Today’s #yclodextrin is about the fantastic progression of the GENEGUT project CarboHyde is part of.

The 5th in-person General Assembly meeting was kindly hosted by our partners at i3S – Instituto de Investigação e Inovação em SaúdeBruno SarmentoCatarina Leite Pereira in Porto, PT 🚀

We (Kristóf Felegyi) reported the chemistry work, which was our part, and now look forward to seeing how these building blocks will perform in RNA delivery and eventually in drug formulation. Caitriona O’Driscoll and Ana Francisca Soares presented some of the promising data at the 21st International Cyclodextrin Symposium last week.

We look forward to interesting discussions, progress updates and networking within the GENEGUT consortium 💡

GENEGUT, Porto, Horizon EUrope

How was the 21st International Cyclodextrin Symposium?

Last week between 10-14 June, the cream of cyclodextrin science gathered in Dunkerque, France to share their knowledge and most recent scientific results during the 21st International Cyclodextrin Symposium.

The conference started with a social tour, visiting nearby sights on the seashore and harbor and spending a wonderful lunch together. We concluded the first-day networking with a welcome party at the Town Hall.

ICS 2024, CarboHyde, Dunkerque

During the event, we could enjoy 81 oral presentations spread across a 3 and half-day scientific fiesta. 166 participants from all around the world (75% Europe, 15% Asia, 10% America) exchanged ideas and initiated collaborations. The most well-represented countries were France, Italy, and Hungary (:P).

During the breaks, we could enjoy bites from French cuisine and discuss further science through the 56 presented posters.

CarboHyde, ICS 2024, Genegut
Caitriona O’Driscoll from UCC giving her keynote

The 1st day was topped by a huge Dunkerque beer&cheese carnival, one of the most memorable social events of all time, while the 2nd one with a wonderful Gala dinner at the stunning nearby aquarium.

ICS 2024, CArboHyde,
Bicyclos team at the Dunkerque Carnival

CarboHyde was represented by two members, Daniel Bisericaru and Tamas Sohajda, and presented a talk about the status, future and dilemmas of developing cyclodextrin-based active ingredients. Further collaborations of the company were dominated by sharing the results of two EU-funded projects: GENEGUT & Bicyclos HEurope.

Several awards were presented during the Symposium:

  • the prestigious Szejtli award went to Sophie Beeren for her groundbreaking work on novel enzymatic methods to create cyclodextrins
  • the best poster award to Ana Francisca Soares from Genegut on CD-based gene delivery
  • the best flash presentation to Martina Dragone discussing peptide-CD interactions
  • the best oral presentation to Clara Testard presenting high-level cyclodextrin synthesis

The conference was concluded by sharing future events where professionals can meet again:

  • Francesco Trotta will organize a CD Summer school in June, 2025 in Geneva, mainly for students
  • The next EUROCD will be held in Milano, September, 2025 as shown by Andrea Mele
  • Keiichi Motoyama invited attendees to Kyoto for the next Asian CD conference to be held in November, 2025.

I hope to see many of you during these events!

It was an amazing experience, huge thanks to the organizers Sophie Fourmentin, Eric MONFLIER and Bernard Martel for their excellent work.

Best wishes, Tamas

β-cyclodextrin polymer as tetrodotoxins scavenger in oyster extracts

Today’s cyclodextrin is a fascinating example of how to use the scavenging capabilities of cyclodextrins to develop tools against natural toxins by Alex Fragoso’s team.

Tetrodotoxins (TTXs) are potent marine neurotoxins involved in humans’ poisoning cases after consuming some marine organisms. In this work, five insoluble cyclodextrin polymers with different chemical structures have been investigated as novel clean-up materials for oyster extracts containing TTXs.

The best recoveries have been achieved with βCDP-14-DS2 (∼100 %), which allowed exposing cells to 27-fold higher oyster matrix concentrations and decreased the LOQ down to 46 µg equiv. TTX/kg.

Then, the applicability of this strategy has been demonstrated with oyster extracts from The Netherlands and comparing the results with immunoassay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). This clean-up strategy combined with CBA could be implemented for TTXs detection in monitoring programs to ensure seafood safety.

β-cyclodextrin polymer as tetrodotoxins scavenger in oyster extracts – ScienceDirect

cyclodextrin, CarboHyde

Few days to go until 21st International Cyclodextrin Symposium

In a few days the global cyclodextrin community gathers in Dunkerque to share thoughts, and results, discuss collaborations and renew friendships.

From CarboHyde‘s perspective, there are several lectures that we look forward to with great excitement:

  1. Francesco Stellacci – our long time collaborator from EPFL , pioneer of using cyclodextrins as antiviral compounds, founder of asterivir
  2. Matthew “Oki” O’Connor – CEO of Cyclarity Therapeutics , a close partner of us doing groundbreaking science of using CDs in atherosclerosis
  3. Tamas Sohajda – CarboHyde CEO delivers a review on using cyclodextrins as active ingredients
  4. Julien Parcq & Damien TRUFFIN – from Roquette, our key partner in cyclodextrin education, discussing critical attributes of CD manufacturing & safety
  5. Milo Malanga PhD – CarboHyde CSO sharing from synthetic challenges
  6. Juan Manuel Benito – Bicyclos HEurope partner, expert in using CDs for gene delivery
  7. Caitriona O’DriscollGENEGUT coordinator, an expert in using CDs for gene delivery
  8. Francesco Trotta & Adrián Matencio Durán, our research partners on nanosponges from University of Turin
  9. Szabolcs Béni – from CarboHyde advisory board and BiCyclos member from Eötvös Loránd University, an expert on CD NMR and analysis
  10. Ilse Manet – BiCyclos coordinator, an expert in CD analysis and applications

And this is just the tip of the iceberg.

21st International Cyclodextrin Symposium, Carbohyde

Our CEO, Tamas Sohajda, presented at CPhI North America

Here are a few words from Tamás about the conference:

A few weeks ago at CPHI North America, I had the pleasure of helping the audience peek into the future of cyclodextrins by showcasing some of the applications we are working on at CarboHyde such as:
– therapeutic cyclodextrins and their development
– using cyclodextrins in vaccines
– using cyclodextrins for gene delivery

I had never spoken at CPHI before, yet it was a fascinating experience, mainly due to James Reidy’s fantastic support.

Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights

Today’s cyclodextrin is about the stabilization effect of CDs on proteins, yet from a different angle.

I shared a lot earlier about the potential of CDs replacing surface active agents, yet how about combining them?

This study from Roquette led by Rajeev Gokhale and Vinod T. investigates the collaborative impact of combining polysorbates and HPβCD as excipients in protein formulations. The introduction of HPβCD in formulations showed it considerably reduced aggregation in two model proteins, bevacizumab and ipilimumab, following exposure to various stress conditions. The diffusion interaction parameter revealed a reduction in protein-protein interactions by HPβCD.

The study suggests that combining these excipients can improve mAb stability in formulations, offering an alternative for the biopharmaceutical industry.

Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights – ScienceDirect

mAb, monoclonal antibodies, carbohyde

CarboHyde – Cyclodextrin live Q&A

Join us for an exclusive LinkedIn Live event as we dive into the intriguing world of cyclodextrins! This dynamic Q&A session features industry experts, researchers, and enthusiasts exploring the diverse applications and cutting-edge advancements in cyclodextrin science.

📅 Date & Time: June 5, 2024, 16:00 CET

📍 Location: LinkedIn Live – Event Link

What to Expect:

  • Expert Insights: Learn about cyclodextrins and their diverse applications.
  • Interactive Q&A: Ask your questions and get real-time answers from experts.
  • Networking: Connect with professionals and researchers in the field.

How to Participate:

  1. Follow our LinkedIn page for updates.
  2. Set a reminder for the event.
  3. Prepare your questions for the Q&A session.

Who Should Attend:

  • Researchers, scientists, and professionals in relevant industries.
  • Students and academics interested in cyclodextrin advancements.

Don’t miss this chance to engage with experts and enthusiasts in cyclodextrin science!

Join us and ask your questions directly to our CEO, Tamas Sohajda.

Register and learn more here: Event Link