when it comes to CDs, mucoadhesive properties are rarely in focus. But why not?
Andreas Bernkop-Schnürch’s team at Leopold-Franzens Universität Innsbruck investigated the mucoadhesive properties of nonionic, negatively, and positively charged thiolated cyclodextrins (CDs), including α-, β-, and γ-CDs of the low and high degree of thiolation.
In conclusion, a high degree of thiolation and the introduction of cationic charges are mainly responsible for the high mucoadhesive properties of CDs and generate, GCD derivatives do better in this aspect.
See the full article here: Thiolated cyclodextrins: A comparative study of their mucoadhesive properties