Cool glyoco-invention got into the light from Zhaohui Sunny Zhou and Amissi Sadiki (Northeastern University), who study methods for making a site-specific modification of a glycoprotein that preserve the charge and glycoform of the glycoprotein. In short, one or more glycans are trimmed from the glycoprotein while keeping a core glycan attached to the glycoprotein. The removal of one or more glycans provides access to a targeted amino acid for a site-specific reaction. The attached core glycan can optionally be utilized for modulation of the glycoprotein, or one or more glycans or reagents can be attached to the core.

See the patent on Espacenet.