It is in the field of imaging. Mie University and Nagoya University has jointly developed an Indocyanine / β-cyclodextrin conjugate suitable for ureter visualization in patients undergoing laparoscopic/minimally invasive colorectal surgery.
Astellas Pharma has acquired exclusive development and marketing rights worldwide (the designation of the compound is ASP5354). A recent clinical trial investigated the safety, tolerability and the pharmacokinetics of ASP5354 in participants undergoing laparoscopic/minimally invasive surgery.
ASP5354 fluoresces upon excitation with a particular wavelength of near-infrared light. When administered intravenously, ASP5354 is primarily and rapidly excreted by the kidneys and provides the surgeon with visualization of the ureter(s) during surgery through the use of a near-infrared fluorescence (NIR-F) medical device.
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