Interesting drug delivery technology targeting abdominal aortic aneurysm by taking alpha-cyclodextrin as a skeleton and bonding a luminol unit. Afterwards, alendronate sodium, polyethylene glycol and lecithin are applied to modify a vascular calcification targeting unit on the surface of the #nanoparticle. The nano-drug is combined with pathological calcified blood vessels of the abdominal aortic aneurysm, so that the off-target effect caused by too high artery blood flow speed is reduced, the targeted enrichment effect on the abdominal aortic aneurysm is enhanced, the inflammatory microenvironment generated at the abdominal aortic aneurysm part can be more effectively inhibited, and the treatment effect of the abdominal aortic aneurysm is improved. The treatment effect of delaying the progress of the abdominal aortic aneurysm is achieved.
CN116271101A Nano-drug for actively targeting abdominal aortic aneurysm and preparation method thereof
