Cyclodextrin polymers have increasing importance, as they are evaluated more and more frequenty in drug delivery solutions and non-pharma applications. This important paper deals with critical aspects of their behavior, such as interaction with human serum albumin, red blood cells bacteria.
Cyclodextrin derivatives and their polymers did not affect the secondary structure content of human serum albumin, which might mean a mild effect on the structural and functional properties of the main blood plasma protein.
Using the hemolysis test, it was found that polymers interact with red blood cells and can be assigned to non-hemolytic and slightly hemolytic groups as biocompatible materials, which are safe for in vivo use.
The cyclodextrins and their polymers did not extract proteins from bacterial cell walls and did not demonstrate any antibacterial activity against Gram-positive and Gram-negative strains.