Topical drug delivery with CDs seems straightforward, even with the extra advantage that CDs can contribute not only as solubilizers but also as permeation enhancers. Still, despite cosmetics, very few products are on the market.
The nano gel concept by Università degli Studi di Firenze (Marzia CirriGiulia NerliNatascia MenniniFrancesca Maestrelli, and Paola Mura) may open some new doors in this area.

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Figure 1. Solubility studies of ibuprofen (IBU) at 25 °C in pH 7.4 phosphate buffer alone (green bar) or in the presence of increasing amounts of HPβCD (blue bars) or EPIβCD (red bars).