A significant advantage of using CDs is that they can contribute to the fast onset, the rapid action of different APIs. This is well highlighted in the patent of Fontana Bio and Catalent Pharma Solutions (Anthony Lando and Leon Grother) describing rapidly disintegrating tablets.
Evaluation of alpha-CD as intestinal tract function improving agent: an immunopotentiating agent, an antimicrobial agent, a hydrogen generator and/or an antioxidant, each comprising CD together with one or more selected from among a butyric acid bacterium, butyric acid, and acetic acid as active ingredients
Nice patent from Cyclochem (Keiji Terao) and Ace Bio Co.
Polyrotaxanes by Toyoda Gosei Americas / ASM and Denka Company Limited / Tokyo Medical and Dental University. The first one is used to make dielectric sheets made of rubber for sensors and actuators; the other promotes osteolysis and/or lipolysis of mesenchymal stem cells (osteoblast or fat differentiation).
These compounds are fascinating and could be so widely used.
It is a little adventure to the nanoworld of Zhengzhou University, which build multi-loaded nanovesicles to encapsulate both hydrophilic and hydrophobic drugs and use them to decrease the formation of foam cells and regulate inflammation.
#nanoparticle #atherosclerosis #drugdelivery