Let’s start the week with an amazing Hungarian paper from University of Pécs.
Cyclodextrin (CD) derivatives deplete cholesterol from membrane rafts in TRPV1 and TRPA1 channels, reducing receptor activation in vitro, anticipating in vivo analgesic effects.
The tested CD derivatives are promising agents for exerting peripheral analgesia and anti-inflammation via cholesterol depletion, also supported by in vitro and in silico findings.
Andrea Nehr-Majoros, Maja Payrits, Noémi Bencze, GYORGY SETALO JR, Rita Börzsei, Csaba Hetényi, Zsuzsanna Helyes, Éva Szőke
