They go (adeno) viral!
1. What Cyclodextrin Brings to Adenoviral Formulations
Hydroxypropyl-β-cyclodextrin (HPβCD) helps stabilize adenoviral vectors by creating a protective environment around the particles, reducing aggregation and degradation.
2. Supporting Complex Purification Workflows
After multi-step purification—such as tangential flow filtration and two-step anion exchange chromatography—cyclodextrin helps maintain the integrity of the highly purified recombinant adenovirus.
3. Enhancing Stability in the Final Drug Product
In the final formulation buffer, HPβCD works alongside excipients like glycerol, sucrose, and polysorbate 80 to improve thermal and storage stability, helping the therapy remain potent over time.
4. Enabling Reliable Delivery of Gene Therapies
By protecting the viral capsid and improving overall formulation robustness, cyclodextrin plays a quiet but vital role in ensuring adenoviral gene therapies reach patients in their intended, effective form.
Minna Hassinen – Ferring Pharmaceuticals – congratulations on the fantastic work!
Espacenet – METHOD FOR THE PURIFICATION OF RECOMBINANT ADENOVIRUS VECTORS
