Today’s cyclodextrin is a nice formulation study from one of the best Hungarian pharmaceutical universities, the University of Szeged, who study various excipients – CDs among others – that have an important role in nasal formulations to increase the permeability of the mucosa and prolong the residence time of the drug.
The charged cyclodextrin-based formulations showed significantly higher adhesive force values regardless of the presence of PVA. The drug release was fast and complete, and the permeation of meloxicam was enhanced.
Patricia Varga, Anett Németh, Scarlett Zeiringer, Eva Roblegg, Budai-Szűcs Mária, Csilla Balla-Bartos, Rita Ambrus
