Today’s cyclodextrin:
Polyrotaxanes are molecular necklaces composed of polymers, threaded macrocycles, and bulky stopper molecules to inhibit the decomposition of the first two.
These supramolecular assemblies are promising active ingredients for treating lysosomal storage disorders.
This study aimed to synthesize such polyrotaxanes with a novel, simple method, resulting in high threading efficacy, enhanced cellular uptake, and intracellular cyclodextrin (CD) release.
Great work from Andreas Bernkop-Schnürch, Gergely Kali and their team at Bernkop-Schnürch Research Group.
