Using CDs for wound healing has been in the spotlight for a long time, many applications and promising prototypes were developed, yet none reached the market.
This may change with the innovation of Jun Li at National University of Singapore who made a smart multifunctional ROS-responsive supramolecular hydrogel.
The polymer is dynamically crosslinked by inclusion complexes of β-cyclodextrin (βCD) and ferrocene (Fc).
This hydrogel facilitates the on-demand release of interleukin-4 (IL-4) while exhibiting intrinsic antibacterial properties.
The system subsequently reprograms macrophages from the proinflammatory M1 phenotype to the anti‒inflammatory M2 phenotype, thereby addressing immune dysregulation in diabetic wounds.
The composition significantly enhanced wound closure, collagen density, and angiogenesis while reducing proinflammatory cytokines (IL-6 and TNF-α) and increasing anti‒inflammatory cytokine IL-10 levels.
Smart multifunctional ROS-responsive supramolecular hydrogel for simultaneously regulating oxidative stress, immune dysregulation, and bacterial infection in diabetic wound healing – ScienceDirect
