1. Be informed about possibilities
The range of cyclodextrins you can use in pharma / nutra / cosmetic products are very different – always understand the full range that you can pick from
2. Check the administration route
The regulatory status – especially in pharma – of the CDs differs. Depending on the admin route you pick, the applicable CDs will be shortlisted
3. Focus on your purpose and the active
There are over a dozen technologies that you can use to create a cyclodextrin complex. Which one you pick should be driven by the characteristics of the active and further processing of the complex
4. Don’t think binary
Cyclodextrin complexation is a sensitive equilibrium that you can influence to your advantage. Many additives can stabilize the complex and help you achieve a higher encapsulation rate and a reduction of cyclodextrin content.
5. Optimize
Once you understand all the components, there are still many aspects of the formulation that favor the complex formation. Temperature, pH, and counterions may all play a crucial role here.
Let’s discuss the details so that you can create the best possible product.
