Today’s cyclodextrin showcases versatility.

Graziella Vecchio‘s team presents the use of Cyclodextrin dimers as potential nanocapsules of biomolecules. The presence of two cavities can improve the stability of inclusion complexes, working as a hydrophilic sandwich of poorly water-soluble species.

The building blocks were functionalized with biotin as a targeting unit and tested the new bioconjugates as doxorubicin delivery systems in cancer cells.

Great work, Noemi Bognanni!

Cyclodextrin Dimers  Functionalized with Biotin as Nanocapsulesfor Active Doxorubicin Delivery against MCF‐7 Breast Cell Line – Bognanni – ChemMedChem – Wiley Online Library