In this creative paper Sven Stegemann, Amrit Paudel (Technische Universität Graz), Chris Moreton (FinnBrit Consulting), Sami Svanbäck (The Solubility Company), Karl Box (Pion Inc.), and Genevieve Motte (JEN Pharma Consulting) analyze trends in oral drug product development.
See the full article here or read the pdf below
It’s worth celebrating this discovery by Genos Ltd – Gordan Lauc, Olga Gornik, Frano Vučković, Ivan Gornik on using predicting type 2 diabetes via N-glycan patterns of plasma proteins. Which inventions make glycochemistry shine and show its importance!
Read the full patent on espacenet
To better understand the place and the goals of CarboHyde, a private preclinical pharma startup from the EU, a short interview was performed with József Tóth Ph.D., Founder, and CEO of CarboHyde.
Read the full interview below in pdf form
Cyclodextrin derivatives were demonstrated to be endowed with intrinsic antiviral action against several viruses (herpes, HIV, RSV, influenza, covid19, etc.). In this great work from Rachele Francese, Francesco Trotta, Claudio Cecone, Matteo Constantino, Gjylije Hoti, Pierangiola Bracco, and David Lembo from the University of Turin, four water-soluble hyper-branched beta cyclodextrin anionic polymer were screened against herpes simplex virus (HSV-2), respiratory syncytial virus (RSV), rotavirus (HRoV), and influenza virus (FluVA). The results suggest that the polymer virucidal activity against RSV can be exploited to produce new antiviral materials to counteract the virus dissemination through the air or direct contact.
An interesting idea proposed by Knut M. Wittkowski for the novel use of alpha-#cyclodextrin:
The effect of alpha-cyclodextrin on post-prandial glucose excursions, a systematic meta-analysis
For more details, click here
Using cyclodextrins, especially 2-hydroxypropyl-beta-CD for the treatment of atherosclerosis has a hype, there are several companies and research groups chasing this holy grail. Fresh from the oven is the patent application from Beren Therapeutics explaining methods of treating familial hypercholesterolemia via different mechanisms of action.
