Now our global player in Centrifugal Partition Chromatography (CPC), RotaChrom Technologies published about Scalable enantioseparation of rac-voriconazole.
Features?
– Batch CPC sets the baseline, intensified to cyclic continuous stacked-injection CPC.
– MDM CPC mode enables continuous injection and dual-outlet product collection.
– MDM CPC intensification delivers an overall ≈25× productivity gain vs resolution.
– Continuous CPC reduces solvent and selector use via repeated phase recycling.
And the best part?
The cyclodextrin, of course. To improve process economics, sulfobutyl ether-β-cyclodextrin (SBE-β-CD) was replaced with lower-cost randomly methylated β-cyclodextrin (RM-β-CD) without compromising the partitioning and selectivity required for MDM operation.
Continuous MDM CPC afforded (2R,3S)-voriconazole at ≥99.8% optical purity and 99.9% enantiomeric excess (ee), with 81% isolated yield
Congrats to Anita Kiss, Dóra Rutterschmid, Szabolcs Muráth!
