Formulation of cyclodextrins?

Today's cyclodextrin, drug discovery

They go (adeno) viral!

1. What Cyclodextrin Brings to Adenoviral Formulations
Hydroxypropyl-β-cyclodextrin (HPβCD) helps stabilize adenoviral vectors by creating a protective environment around the particles, reducing aggregation and degradation.

2. Supporting Complex Purification Workflows
After multi-step purification—such as tangential flow filtration and two-step anion exchange chromatography—cyclodextrin helps maintain the integrity of the highly purified recombinant adenovirus.

3. Enhancing Stability in the Final Drug Product
In the final formulation buffer, HPβCD works alongside excipients like glycerol, sucrose, and polysorbate 80 to improve thermal and storage stability, helping the therapy remain potent over time.

4. Enabling Reliable Delivery of Gene Therapies
By protecting the viral capsid and improving overall formulation robustness, cyclodextrin plays a quiet but vital role in ensuring adenoviral gene therapies reach patients in their intended, effective form.

Minna Hassinen – Ferring Pharmaceuticals – congratulations on the fantastic work!

Espacenet – METHOD FOR THE PURIFICATION OF RECOMBINANT ADENOVIRUS VECTORS

Uses of cyclodextrin polymers.

Today's cyclodextrin, drug development

How about a case study now?From bacterial toxin to long-acting pain relief

Challenge: Chronic & neuropathic pain still largely rely on short-acting, addictive opioids.

Innovation: A β-cyclodextrin polymer that encapsulates mycolactone, turning an insoluble, UV-sensitive molecule into a stable, aqueous formulation.

Chemistry: Crosslinked β-CD forms multiple host–guest cavities, solubilising and protecting mycolactone without organic solvents.

Impact: In vivo, the pCD–mycolactone combo delivers strong, long-lasting analgesia from a single injection — a promising non-opioid alternative for difficult-to-treat pain.

Check out the patent in comments if you like the idea of Ruxandra Gref; Isabelle Marsollier and Estelle Marion. We do so!

Espacenet – LONG-ACTING PAIN-RELIEF FORMULATION

Would you like to design a similar polymer for you application? Let us know, we can help.

Training hard? Consider taking some ACD with your creatine

Today's cyclodextrin, Non-pharma applications,

Exciting research is emerging around α-cyclodextrin (ACD) and its potential role in supporting key aspects of athletic performance.

Traditionally recognized for its unique molecular structure and digestive benefits, ACD is now being explored for targeted applications in sports and human performance.

A recent invention highlights how formulations containing ACD may help support:
• Physical strength and endurance
• Reduced feelings of fatigue
• Improved exercise comfort through moderated heart-rate response
• A healthier gut environment, including the proliferation of Bacteroides uniformis, an important member of the intestinal microbiome

What makes ACD particularly compelling is its versatility, ease of oral administration, and favorable safety profile. The research suggests that consistent daily intake over a period of at least seven days may be key to unlocking these benefits.

As interest in microbiome-centric performance solutions grows, ACD is shaping up to be an intriguing candidate for future innovation in nutrition, wellness, and athletic optimization.

The intersection of gut health and performance continues to expand—and ACD may be one of the ingredients helping to bridge that gap.

carbohyde training

Cyclodextrins – 5 tips for formulators

Today's cyclodextrin, education, ,

1. Be informed about possibilities
The range of cyclodextrins you can use in pharma / nutra / cosmetic products are very different – always understand the full range that you can pick from

2. Check the administration route
The regulatory status – especially in pharma – of the CDs differs. Depending on the admin route you pick, the applicable CDs will be shortlisted

3. Focus on your purpose and the active
There are over a dozen technologies that you can use to create a cyclodextrin complex. Which one you pick should be driven by the characteristics of the active and further processing of the complex

4. Don’t think binary
Cyclodextrin complexation is a sensitive equilibrium that you can influence to your advantage. Many additives can stabilize the complex and help you achieve a higher encapsulation rate and a reduction of cyclodextrin content.

5. Optimize
Once you understand all the components, there are still many aspects of the formulation that favor the complex formation. Temperature, pH, and counterions may all play a crucial role here.

Let’s discuss the details so that you can create the best possible product.

CarboHyde

Sugammadex – Alfaxalone?

drug development,

Present: Sugammadex can be used to reverse rocuronium and similar NMBA.
The future: Alfaxalone?

This rat study shows that Sugammadex can reverse the anesthetic effects of alfaxalone.

Recovery speed from alfaxalone anesthesia is dependent upon sugammadex dose and sex.

Obviously, its not working as well as for the original target (Compared to saline controls, sugammadex shortened recovery times by 40%–60% following anesthesia induction) but the repurposing idea is nice.

What do you think? Can a scavenger like this be repurposed for other applications?

Use of Sugammadex to Reverse Alfaxalone Anesthesia in Rats – ScienceDirect

22nd International Cyclodextrin Symposium

news,

Moga, Punjab, India – ISF College of Pharmacy (An Autonomous College), Moga, is proud to announce that it will host the 22nd International Cyclodextrin Symposium (ICS22) from October 22-26, 2026. This marks a historic milestone as the first time this prestigious international symposium is being held in India.

The symposium, themed “Integrating Cyclodextrin and AI Techniques for Next-Generation Novel Drug Delivery Systems,” will bring together more than 500 leading scientists, researchers, academicians, and industry professionals from over 40 countries to discuss groundbreaking advances in cyclodextrin chemistry and its revolutionary applications in pharmaceutical sciences.

The symposium will cover diverse topics including:
# Cyclodextrin chemistry and characterization
# Novel drug delivery systems
# AI and machine learning in pharmaceutical formulation
# Nanotechnology applications
# Industrial perspectives and commercialization
# Regulatory aspects and quality control
# Clinical applications and case studies