When Cyclodextrin’s Two Homes Met in Kyoto

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Last week, Kyoto hosted the 12th Asian Cyclodextrin Conference, bringing together researchers, collaborators, and long-time friends from around the world — including several members of Bicyclos HEurope.

For us at CarboHyde, the event felt like a reunion between the two main “homes” of cyclodextrin science.
Japan has long been a cradle of CD innovation, while Hungary has become another strong home driving cyclodextrins toward new applications and industries. Seeing these two hubs reconnect in Kyoto was inspiring.

Our CSO, Milo Malanga, PhD, was also present — the smiling, chatty Italian in jeans who never misses the chance to ask a sharp question after each lecture. His presence helped spark new conversations and strengthen ongoing collaborations.

The conference offered what makes this community so special: solid science, meaningful dialogue, and friendships that push the field forward.

We return from Kyoto with renewed motivation — ready to turn last week’s ideas into future cyclodextrin innovations.

Connecting biotechnology, agriculture, and pharmaceuticals

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We at CarboHyde are proud to see our collaboration with Allbiom – Inteligência em Bioprocessos represented at the CIFARP – International Congress of Pharmaceutical Sciences!

The joint research presented by Lilian Pontes and Amanda Brandão, under the leadership of Dr. Ana Carolina Ré, beautifully demonstrates how cyclodextrins can serve as molecular bridges between agro- and pharma-biotechnology — enabling smarter delivery systems, modulation of microbial processes, and new bioproduction strategies.

This collaboration reflects CarboHyde’s mission to expand the application horizon of cyclodextrins beyond traditional boundaries — harnessing their supramolecular chemistry to open new routes in sustainable innovation.

A big thank you to our partners at Allbiom for their scientific excellence and inspiring teamwork. We’re excited to see where this synergy will lead next!

Finally, girl power!

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It took us much longer than planned and than what we hoped, yet now we are on the right track.

We are super happy to have a bright young talent, such as Janka Juhász joining the CarboHyde team.

The cyclodextrin hard-core science space just became a bit more vivid and colorful.

Are all SBECDs and HPBCDs created equal?

Today's cyclodextrin

Hardly.

That’s what you can also learn from this recent patent by Thorbjørn Terndrup Nielsen, Kim Lambertsen Larsen and Lars Wagner Städe form Aalborg University.

In the work they created some specially substituted CDs and compared their performance to commercial analogues.

Got curious which performed better? Let’s find out:

WO2025229196 PRIMARY SIDE MODIFIED SULFOALKYL ETHER- AND HYDROXYPROPYL-CYCLODEXTRINS, SYNTHESIS AND USE THEREOF

When Molecules Fall in Love

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“The chemistry works between us.”
Have you ever felt that way?

Well, cyclodextrins certainly have. When they meet the right molecule, it’s more than just an interaction — it’s a connection.

At PODD 2025, our colleague Tamás Kiss, PhD, shared something truly close to CarboHyde’s heart: a story about chemistry, but not the kind you find only in a lab. His presentation told a love story between two molecules — one that perfectly captures the essence of what we do.

One of the molecules was a bit unstable, unpredictable, and easily lost its direction when left on its own. It needed balance, support… maybe even a partner.

And then, it met a cyclodextrin.

Inside the cyclodextrin’s cavity, everything changed. Stability improved, solubility increased, and performance reached new levels. Together, they became stronger, more functional, and far more impressive than either could ever be alone.

That’s the beauty of cyclodextrins — they don’t just interact, they transform relationships at the molecular level.

At CarboHyde, we believe in this kind of chemistry — the kind that turns potential into performance and makes science feel a little like magic.

PODD_2025_CarboHyde_Tamás Kiss_pdf versionDownload

Ooops, we did it again

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This time our flourishing GENEGUT collaboration produced a great paper on the SAR investigations of cyclodextrins in gene delivery.

This topic is essential to understand how cyclodextrins actually work when encapsulating different oligos and what are the ideal structures for the nanoparticle formation loading and transfection.

Got your attention?

Huge admiration to our collaborators, Ayse Kont, PhD, Monique Mendonca, PhD, Andrew Lindsay, Michael Cronin, Mary Cahill and Caitriona O’Driscoll

And last but not least, our team members, Milo and Kristóf.

The impact of cyclodextrin architecture and charge for optimized nucleic acid delivery: A comparison of monomers, dimers, and polymers – ScienceDirect

Cyclodextrin Masterclass – Your time to shine

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The Cyclodextrin Masterclass series has become a cornerstone for education and science communication in the field, fostering knowledge exchange and collaboration among researchers, students, and industry experts worldwide. Over its ten editions, it has helped bridge fundamental science and applied innovation, supporting the growth of the global cyclodextrin community and inspiring new generations of scientists.

As we approach the 10th edition, we invite researchers to present their cyclodextrin-related work in a 15-minute talk (10 min presentation and 5 min Q&A) at one of our upcoming Masterclasses.

If you’d like to share your research, please send a short abstract to tamas.sohajda@carbohyde.com.

Removal of per- and polyfluoroalkyl substances

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We have already seen many cyclodextrin-based approaches to the problem. Some more scientific, others, like that of Cyclopure, completely practival.

This review from Dario Lacalamita, Chiara Mongiovì, Grégorio Crini & Nadia Morin-Crini collects the strategies of CDs dealing with forever pollutants.

Cyclodextrin-based materials include cross-linked compounds, molecularly imprinted polymers, covalent organic frameworks, and silica hybrids.

Cyclodextrin-based materials are much more efficient for the remediation of per- and polyfluoroalkyl substances, because these cage molecules can be designed to specifically recognize pollutants.

As a consequence, cyclodextrin-based materials display much higher adsorption coefficients, in the range of 104—106 L per Kg, compared to less than 104 L per Kg for activated carbon.

Cyclodextrins for the removal of per- and polyfluoroalkyl substances: a review | Environmental Chemistry Letters