Dr. Milo Malanga on what are cyclodextrins?

education,

🔎 In this video, Milo Malanga from CarboHyde explains how cyclodextrins are being harnessed to support the safe and effective delivery of RNA-based therapies for Crohn’s disease within the GENEGUT project.

🔬 GENEGUT is developing a first-in-class oral RNA-based therapy to target intestinal inflammation at its source, and cyclodextrins are playing an essential role.

The RNA delivery will be enabled by a combination approach using novel Biomaterials, including patented amphiphilic cyclodextrins and amino polyesters, are designed to protect and carry RNA through the gastrointestinal tract by forming nanoparticles.

Podcast alert – the Carbohydrate Chronicles is back with Season II

Today's cyclodextrin, , ,

🚀 Cyclodextrins: Beyond Pharma! 🚀
From dietary supplements and cosmetics to energy, agriculture, and even space exploration, cyclodextrins are transforming industries in unexpected ways. 🌍✨
Curious about their potential? Tune into the podcast to explore the science and real-world applications of these versatile molecules! 🎧


Subscribe for updates and more episodes: (3) Season 2 – Episode 1 – cyclodextrins beyond pharma | LinkedIn

Cyclodextrin Masterclass V

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Ready to take your cyclodextrin knowledge to the next level?

Join us for the fifth edition of the CarboHyde Cyclodextrin Masterclass, where we’ll dive deep into the technical intricacies of crafting effective cyclodextrin complexes and formulations. Whether you’re optimizing a drug delivery system or evaluating product compositions on the market, this session will arm you with practical insights and proven strategies.

Registering here is necessary to receive link to attend: https://www.carbohyde.com/cyclodextrin-masterclass-v-how-to-make-a-cyclodextrin-complex/

💡 What You’ll Learn:

Technical best practices for developing cyclodextrin complexes
Key formulation challenges—and how to overcome them
Real-world analysis of existing cyclodextrin-based products
Expert tips to improve stability, solubility, and efficacy
Presented by Dr. Tamas Sohajda (CarboHyde), this masterclass is a unique opportunity to explore the “how-to” behind successful cyclodextrin applications in pharma.

🎯 Who Should Attend?
Formulation scientists, R&D specialists, pharmaceutical developers, and anyone working hands-on with cyclodextrins.

Polyvinyl alcohol, N-acetylcysteine, and methyl-β-cyclodextrin exhibit albumin functions in natural killer cell culture

Today's cyclodextrin,

Today’s cyclodextrin is about replacing albumin with a magic combo of Polyvinyl alcohol, N-acetylcysteine, and methyl-β-cyclodextrin.
Albumin is a crucial component of serum-free media, playing a significant role in ex vivo cell culture as a lipid carrier and antioxidant.
Polyvinyl alcohol (PVA), N-acetylcysteine (NAC), and methyl-β-cyclodextrin (M-β-CD) were tested as an albumin substitute combination (PNM) and optimized their concentrations by using response surface methodology.
Verification of functions of PNM showed that intracellular fatty acid levels, cholesterol consumption rates, and the pSTAT5 level in the PNM group were significantly higher than those in the 0.75 g/L BSA group.

Reactive oxygen species levels remained controlled, and mitochondrial membrane potential was similar. These findings suggested that the PNM can effectively replace the functions of BSA as a fatty acid carrier, antioxidant, and, to some extent, a cholesterol carrier. This study provides insights for developing chemically defined media to prepare clinical-grade NK cells efficiently.

Polyvinyl alcohol, N-acetylcysteine, and methyl-β-cyclodextrin exhibit albumin functions in natural killer cell culture – ScienceDirect

“Biotechnologists’ Days Expo and Conference in Budapest

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We are going to participate in the “Biotechnologists’ Days Expo and Conference,” where university students can meet several companies in the biotech field in Hungary.
Tamas Kiss, will represent CarboHyde with Balázs Attila Kondoros and Tamás Vargadi.

Balázs will give a presentation, and we will also bring a poster to introduce our company and our biotech topics.

Hope to see many young talents there!

“Wash-free” synthesis of cyclodextrin metal–organic frameworks†

Egyéb kategória

Have you ever made a CD-MOF?

These guys make it seem pretty easy!

They propose a simple and fast synthetic strategy for preparing highly crystalline γ-cyclodextrin-based metal–organic frameworks (solid yield 100%). This is the first method that allows metal–organic frameworks with high surface areas to be synthesised without a washing step.

“Wash-free” synthesis of cyclodextrin metal–organic frameworks – RSC Mechanochemistry (RSC Publishing)

Theratechnologies Receives FDA Approval for EGRIFTA WR™

Today's cyclodextrin, drug delivery

Today’s yclodextrin:
I have often been asked about the CD-based products delivered subcutaneously by many partners.

I always had to refer to research and clinical trials, yet there were no marketed products.Now, that era is over, here you can see the first s.c. delivered, HPBCD-supported drug (Tesamorelin F8 by Theratechnologies Inc.) approved by the FDA:
Theratechnologies Receives FDA Approval for EGRIFTA WR™ (Tesamorelin F8) to Treat Excess Visceral Abdominal Fat in Adults with HIV and Lipodystrophy | Theratechnologies Inc.

Tesamorelin for injection is the only medication approved in the U.S. for the reduction of excess abdominal fat in adults with HIV who have lipodystrophy.