New cyclodextrin patent for agricultural application

Today's cyclodextrin

Today’s cyclodextrin is my next cyclodextrin patent.

I have been advocating for improved solutions for agriculture formulations for a long time.

Cyclodextrins can help improve the biological activity and uptake of pesticides and insecticides, improve their penetration, reduce their applied dose (and burden on the environment) and even achieve controlled release of these agents.

US20250057161 USE OF CYCLODEXTRINS AS AGROCHEMICAL DELIVERY SYSTEM


This is what our patent with ADAMA Ltd. is about.
Shimon Amselem, Lital Koren, Zoltán Fülöp, István Puskás

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential

Today's cyclodextrin

Hungarian cyclodextrin science flourishes!

This paper by Horváti Kata & Chiara Bellini et al is about formulating lipopeptides.

Formulation with the randomly methylated α-cyclodextrin (RAMEA) and the sulfobutylether-β-cyclodextrin (SBECD) has resulted in the production of ultralow-sized molecular dispersion systems and reduced lipopeptide toxicity without compromising its antimicrobial activity.

Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential – Bellini – Aggregate – Wiley Online Library

Inhibitor inclusion complex nitrogen fertilizer compositions

Today's cyclodextrin

Today’s cyclodextrin is about an agricultural application from SABIC.

In this invention, Sabic uses cyclodextrin for fertilizing via encapsulating urease inhibitors in a solidified nitrogen fertilizer melt.

The inhibitor (e.g., a nitrification and/or urease inhibitor), when complexed with the cyclodextrin, can be thermally stable at temperatures (e.g., 140 °C or more) exceeding the melt temperature of the nitrogen fertilizer. This can be advantageous in that the complexes can be contacted with and dispersed throughout molten nitrogen fertilizer with reduced, minimal, or no degradation of the inhibitors.

WO2025032113 INHIBITOR INCLUSION COMPLEX NITROGEN FERTILIZER COMPOSITIONS

Update Bridion Prescribing Information for pediatric patients from birth to less than 2 years of age

Egyéb kategória

Merck submitted supplemental new drug application which was received on June 12, 2024 by FDA for Bridion® (sugammadex) injection.

This request proposed to update Bridion Prescribing Information for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in pediatric patients from birth to less than 2 years of age.

Followed by Merck’s request, Bridion injection has been approved on December 12, 2024 for use in pediatric patients ages from birth to less than 2 years old for reversal of neuromuscular blockage induced by rocuronium bromide and vecuronium bromide.

Source: FDA 022225Orig1s014ltr.pdf

Bridion, CarboHyde

Nasal delivery with cyclodextrins

carbohydrates, ,

The development project of Università di Pavia is a fantastic example of combining excipients.

Mucoadhesive and thermo-responsive in situ gelling systems were developed for nasal delivery, using hydrophobically-modified hydroxypropyl-methyl cellulose (Sangelose, SG) and beta-cyclodextrin (β-CD) derivatives, for preventing viral respiratory infections.

Silvia Rossi, Barbara Vigani & colleagues


Development of a nasal spray based on cyclodextrin/hydrophobically-modified hydroxypropyl-methyl cellulose for the prevention of viral respiratory infections – ScienceDirect

carbohyde

Today, we became 3 years old

news

So officially nursery is over, we are almost fully grown now and can start kindergarten.

No more diapers needed and we can use the scissors too.

We ae sincerely grateful for all the support we received during our first years from partners, collaborators, friends and colleagues. Without you, creating this workshop of cyclodextrin innovation would not have been possible.

so THANK YOU!

And feel free to serve yourself from the cake. When in Budapest, step by and be our guest.

Bad Hair Day? Cyclodextrins to the Rescue!

Today's cyclodextrin,

today’s cyclodextrin:
It’s Monday.
You are not in the mood to get up. To work.
And your hair sucks too.

But cyclodextrins can help!

Cyclodextrins were not yet utilized in personal care products in 1978, during the golden era of shiny hairstyling epitomized by the release of Grease. Had they been available, John Travolta could have made great use of the innovation described here. Tokyo-based Arimino Co., Ltd., founded in 1946 and specializing in hair and skin cosmetics—including hair color, styling products, shampoos, and skincare—has introduced a breakthrough product: Arimino Men Freeze Keep Grease. This scented hair grease for men incorporates native beta-cyclodextrin and hydroxypropyl beta-cyclodextrin as fragrance-retention agents. According to the company’s website (https://www.arimino.co.jp/), the product exemplifies their innovative use of cyclodextrins, which are featured across numerous offerings on their site. Among these, Arimino Men Freeze Keep Grease stands out as a truly remarkable development.