Griffith University (Oren Cooper, Dechao Chen, Thomas Haselhorst, Joseph Tiralongo et al) and University of Bremen released common findings on creating multivalent siglec probes through the decoration of α(2,6)-sialyllactose ligands on inherently fluorescent carbon dots capable of generating a significant cytotoxic effect on Burkitt’s Lymphoma (BL) Daudi B cells.
Turbine Raises €20 Mn to Advance Its Cancer Cell Simulation Platform.
Turbine leverages its technology by identifying associated biomarkers and combination strategies and selecting in vitro and in vivo biological models for experimental validation. Turbine partners with biopharmaceutical companies seeking to deploy simulations to understand patients and overcome causes of resistance hindering drug development in the clinic.
See the full article on BusinessWire
I.
Great review from Universidade de Coimbra (Ana Cláudia Paiva-Santos, Laura Ferreira, Filipa Mascarenhas Melo, Sofia Rabaça, Francisco Veiga), Mewar University (Dr. Ankita Mathur), Sharda University, University at Buffalo (Dr. Prabhanjan Giram), Shivaji University, University of Zabol (Abbas Rahdar), Shanghai Jiao Tong University (Faisal Raza 费赛), Faculdade de Ciências Farmacêuticas – Unicamp (ENG: Pharmacy School – University of Campinas) (Priscila Mazzola) on dermatology and cosmetic applications
II.
Beta-Cyclodextrins as affordable antivirals to treat coronavirus infection
III.
Honestly, I am not sure how mankind will handle medication related to space travel. That will be a huge challenge that needs to be studied asap. Recently, the interaction behavior of remdesivir with CDs was studied at ISS (pp 53)
IV.
How cool is it that you can use CDs to stabilize antigens? Super cool 🙂
Polypseudorotaxane hydrogels based on cyclodextrin and polyethylene glycol significantly improved the stability of antibody preparations and showed no serious adverse effects after subcutaneous injection, suggesting the possibility as safe vaccine formulations to stabilize an antigen protein.
Daiichi University of Pharmacy
Kumamoto University, JAPAN
Hiroshi Itou Hidetoshi Arima Keiichi Motoyama
V.
Enrichment of bread with α-CD resulted in positive effects on postprandial glycaemia and induced satiety. The incorporation of encapsulated hydroxytyrosol offered similar overall acceptability due to the bitter taste-masking effect provided by α-CD and a slightly additional positive effect in postprandial glycaemia and satiety. The development of foods with favorable metabolic effects is of great importance for the prevention of chronic diseases. The study was prospectively registered in clinicaltrials.gov (NCT04725955, date: 27th January 2021).
Harokopio University of Athens – Panagiota Binou, Athena Stergiou, Nikolaos Tentolouris, Vaios K.
VI.
Is the humid autumn whether messing up your hair? Keep calm and use CD-formulations (L’Oréal invention – Cho-Cho Khine and Ronak Rughani) for providing lasting curl definition and/or frizz and/or volume control to hair, even in high humidity.
Our CSO, Milo Malanga PhD spent the last week at Università degli Studi di Torino in the lab of Francesco Trotta, supporting students in their chemistry visions and creating nanosponges together as well as delivering a scientific seminar on the uses of cyclodextrin in biotechnology. We will explore together the potential uses of the created compounds as novel drug delivery systems in the coming months. Next year CarboHyde will host students from the Trotta lab to continue the synthetic work and create new compounds supporting our collaborative R&D program.
After reporting on intracellular protein delivery yesterday, today we share the latest news on RNA delivery to prostate cancer cells using cyclodextrin nanoparticles.
Universidad de Castilla-La Mancha, Instituto de Salud Carlos III, Universidad de Sevilla (Jose Manuel Garcia Fernandez, Valentin Ceña et al)
Now, this is something we have never seen before. Delivering oligonucleotides into cells using cyclodextrin-based nanoparticles has been studied a lot, yet in the paper from Chongqing University, intranucleus delivery of proteins is shown. This will certainly open up new drug delivery possibilities for the future and trigger novel applications.
Read the full article on ScienceDirect
Amazing therapeutic success led by UCSF Pediatrics joined by Duke University, Ottawa University, and Washington University via in-utero enzyme-replacement therapy for infantile-onset Pompe’s disease: Patients with early-onset lysosomal storage diseases are ideal candidates for prenatal therapy because organ damage starts in utero. After receiving in-utero ERT and standard postnatal therapy, the current patient had normal cardiac and age-appropriate motor function postnatally, was meeting developmental milestones, had normal biomarker levels, and was feeding and growing well at 13 months of age.
Heartwarming to see such important findings published by Hungarian researchers on the effects of Hydroxypropyl-beta-cyclodextrin on Cultured Brain Endothelial Cells. Cytotoxicity, permeability, and cellular internalization of HPBCD on primary rat and immortalized human (hCMEC/D3) brain capillary endothelial cells were investigated, which can help to develop new strategies for improved HPBCD effects after systemic administration.
We have been waiting for this review for a long time. #cyclodextrin in lysosomal storage diseases!
Huge thanks to Kumamoto University, JAPAN and Saga University
We participated at the biggest pharmaceutical exhibition, CPhI Worldwide in Frankfurt in November 2022, represented by Gergely Tóth, CFO and Tamas Sohajda, board member.
This was the first international exhibition where CarboHyde participated in looking for new partners, suppliers, and CMOS for our upcoming programs. The event was a huge success and triggered several collaborations on the R&D and commercial sides.
